Nova técnica parecer ser o caminho para cura da AIDS. A técnica consiste no uso da vacina da febre amarela + fração do vírus SIV (AIDS dos macacos) que confere resistência contra o vírus. Feito isso e injetados nos macacos a vacina, todos os macacos adquiriram resistência ao SIV (AIDS do macaco).
Veja o vídeo explicando como funciona:
http://www.youtube.com/watch?v=kqMTXyCY2rU
O Artigo foi publicado na revista Nature o mais importante meio de publicação do meio cientifico.
Vaccine-induced CD8+ T cells control AIDS virus replication.
Mudd PA, Martins MA, Ericsen AJ, Tully DC, Power KA, Bean AT, Piaskowski SM, Duan L, Seese A, Gladden AD, Weisgrau KL, Furlott JR, Kim YI, Veloso de Santana MG, Rakasz E, Capuano S 3rd, Wilson NA, Bonaldo MC, Galler R, Allison DB, Piatak M Jr, Haase AT, Lifson JD, Allen TM, Watkins DI.
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53711, USA.
Developing
a vaccine for human immunodeficiency virus (HIV) may be aided by a
complete understanding of those rare cases in which some HIV-infected
individuals control replication of the virus. Most of these elite
controllers express the histocompatibility alleles HLA-B*57 or HLA-B*27
(ref. 3). These alleles remain by far the most robust associations with
low concentrations of plasma virus, yet the mechanism of control in
these individuals is not entirely clear. Here we vaccinate Indian rhesus
macaques that express Mamu-B*08, an animal model for HLA-B*27-mediated
elite control, with three Mamu-B*08-restricted CD8(+) T-cell epitopes,
and demonstrate that these vaccinated animals control replication of the
highly pathogenic clonal simian immunodeficiency virus (SIV) mac239
virus. High frequencies of CD8(+) T cells against these Vif and Nef
epitopes in the blood, lymph nodes and colon were associated with viral
control. Moreover, the frequency of the CD8(+) T-cell response against
the Nef RL10 epitope (Nef amino acids 137-146) correlated significantly
with reduced acute phase viraemia. Finally, two of the eight vaccinees
lost control of viral replication in the chronic phase, concomitant with
escape in all three targeted epitopes, further implicating these three
CD8(+) T-cell responses in the control of viral replication. Our
findings indicate that narrowly targeted vaccine-induced virus-specific
CD8(+) T-cell responses can control replication of the AIDS virus. Nature 2012 Nov 1;491(7422):129-33
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